RAPID COMMUNICATION Interleukin-3 (IL-3) Poor-Responsive Inbred Mouse Strains Carry the Identical Deletion of a Branch Point in the IL-3 Receptor
نویسندگان
چکیده
Interleukin-3 (IL-31 stimulates colony formation of multiple lineages of hematopoietic cells. Bone marrow cells of A/J mice are nonresponsive to IL-3, and this observation has recently been correlated with aberrant mRNA splicing and impaired expression of the IL-3 receptor a subunit (IL-BRa). a binding component of the high-affinity receptors. We examined the IL-3Ra gene in 27 inbred mouse strains and found the identical mutation, a 5-bp deletion at the branch point of intron 7, in 10 of these mouse strains. Bone marrow cells isolated from these 10 mouse strains did not express
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